Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble
Selected Publications
Asaf Marco, Hiruy S Meharena, Vishnu Dileep, Ravikiran M Raju, Jose Davila-Velderrain, Amy Letao Zhang, Chinnakkaruppan Adaikkan, Jennie Z Young, Fan Gao, Manolis Kellis, Li-Huei Tsai
In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development
Sari Schokoroy Trangle, Tali Rosenberg, Hadar Parnas, Gilad Levy, Ela Bar, Asaf Marco, Boaz Barak
List of Publications
• Trangle SS, Rosenberg T, Parnas H, Levy G, Bar E, Marco A *#, Barak B *# In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development. Mol Psychiatry. 2022 Dec 28. doi: 10.1038/s41380-022-01921-z.
• Rosenberg T *, Marco A * PI , Kisliouk T, Haron A, Shinder D, Druyan S, Meiri N # . Embryonic heat conditioning in chicks induces transgenerational heat/immunological resilience via methylation on regulatory elements. FASEB J. 2022 Jul;36(7):e22406. doi:10.1096/fj.202101948R.
• Meharena H, Marco A, Dileep V, Young JZ, Gao F, Kellis M, Tsai LH. Down Syndrome Induced Senescence Disrupts the Nuclear Architecture of Neural Progenitors. Cell Stem Cell. 2021.
• Ben-Nun O, Kisliouk T, Marco A PI, Rosenberg T, Meiri N #. Early-life thermal stress mediates long-term alterations in hypothalamic microglia. Glia. 2021.
• Marco A# PI. Activity-dependent remodeling of genome architecture in engram cells facilitates memory formation and recall. Invited review. Neural Regen Res. 2021 May;17(5):991-993. doi: 10.4103/1673-5374.324834.
• Marco A# C, Meharena H C, Dileep V C, Raju R C, Davila VJ C, Zhang A S, Adaikkan C C, Young JZ C, Gao F C, Kellis M C, Tsai LH PI #. (2020). Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nature Neuroscience. doi.org/10.1038/s41593-020-00717-0.
• Adaikkan C C, Middleton SJ C, Marco A C, Pao PC C, Mathys H C, Kim DN S, Gao F C, Young JZ C, Suk HJ C, Boyden ES C, McHugh TJ C, Tsai LH PI. (2019). Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. 102(5):929-943.
• Tabachnik T S, Kisliouk T C, Marco A S, Meiri N C,PI, Weller A PI. (2017). Thyroid Hormone-Dependent Epigenetic Regulation of Melanocortin 4 Receptor Levels in Female Offspring of Obese Rats. Endocrinology. 158(4):842-851.
• Barnea R S, Bekker L S, Zifman N S, Marco A S, Yadid G C,PI, Weller A PI. (2017). Trait and state binge eating predispose towards cocaine craving. Addict Biol. 22(1):163-171.
• Marco A S, Kisliouk T C, Tabachnik T S, Weller A C,PI, Meiri N PI. (2016). DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring. Diabetes. 65(8):2258-67.
• Marco A# S, Kisliouk T C, Meiri N C,PI, Weller A PI. (2014). Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not "reprogrammed" by regular chow diet in rats. FASEB J. 28(9):4148-57.
• Marco A# S, Kisliouk T C, Weller A C,PI, Meiri N PI. (2013). High fat diet induces hypermethylation of the hypothalamic Pomc promoter and obesity in post-weaning rats. Psychoneuroendocrinology. 38(12):2844-53.
• Marco A# S, Schroeder M S, Weller A PI. (2012). Feeding and Reward: Ontogenetic changes in an animal model of Obesity. Neuropharmacology. 62(8):2447-54.
• Marco A S, Schroeder M S, Weller A PI. (2009). Microstructural pattern of palatable food intake from weaning to adulthood in male and female OLETF rats. Behav Neurosci. 123(6):1251-60.
• Schroeder M S, Shbiro L S, Marco A S, Zagoory-Sharon O C, Hyun J S, Moran TH C,PI, Bi S C,PI, Weller A PI. (2009). Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat. Am J Physiol Regul Integr Comp Physiol. 297(6):R1749-60.
​