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The Marco Laboratory for Neuro-Epigenetics

We study how experience-driven brain activity shapes the epigenome and the 3D- chromatin architecture, in both healthy and diseased states

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Research Interests 

Our laboratory examines how different environmental stimuli shapes the brain epigenome and regulates chromatin organization.  We are particularly interested to understand how this process leads to long-lasting changes in gene expression, neuronal activity and behavior.

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Our research focuses on three key areas:


1. Epigenetic Mechanisms Underlying Hypothalamic Circuits of Appetite and Energy Balance Control.

 

2. Adaptive Chromatin Responses Induced by Intermittent Fasting Regimes as a Tool to Improve Brain Health and Cognitive Performance.


3. Molecular and Epigenetic Mechanisms Underlying Memory Formation and Recall 

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Latest Publications

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Israeli study uncovers how Williams syndrome disrupts brain development
The syndrome in the past has been estimated to occur in about one in every 20,000 live births, but more recently, it's closer to one in ever 7,500 live births.
In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development
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